Prof. Janis Klovins is the director of LBMC and head of one of the largest groups at LBMC, the Group of Human Genetics and Molecular Medicine. He has more than 20 years of experience in molecular biology, biobanking and genetic epidemiology. He established Latvian Genome Centre, the main genotyping and sequencing facility in Latvia, is a current director of BMC and was one of the initial co-founders and head of Latvian Genome Database (LGDB) biobank comprising more than 33000 participants. Prof. Klovins has led over 20 scientific projects and participated in international collaborations. He will perform the study design, supervision of research work, writing and drafting the papers for the project.

Prof. Eran Segal is a Professor at the Computer Science and Applied Mathematics Department at the Weizmann Institute of Science. He has a B.Sc. in Computer Science (summa cum laude, 1998, Tel-Aviv University), and a Ph.D. in Computer Science and Genetics (2004, Stanford University). He completed an independent postdoctoral research position at Rockefeller University, New York, and took a faculty position at the Weizmann Institute since 2005. Prof. Segal heads a multi-disciplinary team of computational biologists and experimental scientists at the Department of Computer Science and Applied Mathematics at the Weizmann Institute of Science. He received an ERC starting grant in 2007 and currently holds an PF7 consolidator ERC grant. Prof. Segal received several awards and honors for his work, including the Overton prize, awarded annually by the International Society for Bioinformatics (ICSB) to one scientist for outstanding accomplishments in the field of computational biology, and the Michael Bruno award. He was recently elected as an EMBO member and as a member of the young Israeli academy of science. He published more than 100 research articles in international, peer-reviewed journals, of which more than 20 appeared in Science, Cell, or Nature and its sub-
journals. One of his Nature papers was ranked #6 in MolecularBiologyand #9Bioinformatics and
Computational Biology in the all-time rankings of the Faculty of 1000 website our of >100,000 papers published by January 2015.

Prof. Janis Klovins is the director of LBMC and head of one of the largest groups at LBMC, the Group of Human Genetics and Molecular Medicine. He has more than 20 years of experience in molecular biology, biobanking and genetic epidemiology. He established Latvian Genome Centre, the main genotyping and sequencing facility in Latvia, is a current director of BMC and was one of the initial co-founders and head of Latvian Genome Database (LGDB) biobank comprising more than 33000 participants. Prof. Klovins has led over 20 scientific projects and participated in international collaborations. He will perform the study design, supervision of research work, writing and drafting the papers for the project.

Dr. Davids Fridmanis defended his bachelors (2003), masters (2004) and PhD (2011) thesis in University of Latvia on molecular, functional and evolutional research of Melanocortin receptors. During his studies on several occasions he received FEBS short term fellowships for conduction of his research at Neuroscience department of Uppsala Biomedical Centre, University of Uppsala. After the establishment of the Genome Centre he became the head of genetic analysis division and currently holds the place within the LBMC purchase committee. In parallel to these activities Davids is also a head of small, newly formed LBMC research group that focuses on functional research of G-protein coupled receptors, and the head of LBMC Bioinformatics Core facility. Davids Fridmanis has 30 peer-reviewed international publications.

MSc. Monta Ustinova is one of the assistants for Principal Investigator in the currently ongoing clinical trial in LBMC. In addition, she has previously gained expertise in RNAseq data analysis, and is one of the certified specialists performing mice experiments in newly established animal facility at the LBMC. Monta has participated in multiple scientific projects related with personalized medicine and as a secretary of Latvian Association of Human Genetics she is improving the communication between the scientific community and physicians.

Prof. Ewan Pearson is Professor of Diabetic Medicine at the Division of Cardiovascular & Diabetes Medicine at the University of Dundee. His research interests are in stratification of diabetes based upon drug response; difference in aetiology or difference in progression rate of diabetes. He established that patients with particular monogenic forms of diabetes could be treated differently to ‘normal’ diabetes – e.g. HNF1A MODY (Pearson et al. Lancet 2003) and KCNJ11 neonatal diabetes (Pearson et al. NEJM 2006) and was the first to publish a GWAS of drug response in diabetes pharmacogenomics of diabetes drug response (Zhou et al. Nature Genetics 2011) and now leads the Metformin Genetics Consortium which has recently identified that variants in SLC2A2 are robustly implicated in metformin response (Zhou et al. Nature Genetics 2016) but that loss of function variants in the organic cation transporters are not (Dujic et al. Clin Pharm Therapeutics, 2016) are not.. Ewan is the academic lead for the €46M IMI‐DIRECT project on stratification of diabetes, and holds Wellcome Trust New Investigator award.